City are held to a goalless draw by Queens Park Rangers, despite dominating possession and creating the better chances throughout a frustrating 90 minutes.
Chris Coleman made three changes to the side which lost 2-1 against Scunthorpe on Saturday.
Elliott Ward replaced Marcus Hall at centre-back, while Stephen Hughes came in for Michael Hughes in the centre of the park. Hughes is also named as skipper ahead of Michael Doyle, who started in place of Julian Gray.
Coventry thought they'd made the best possible start in the fourth minute when Scott Dann found the back of the net from a Doyle ball, only for the goal to be disallowed.
The Sky Blues attacked again and in the ninth minute, Coleman's men created a great opportunity to open the scoring.
Thornton found Best on the right hand side of the pitch and the striker played an inch-perfect ball back across the box for Ward, who lifted his shot over the crossbar.
City were certainly dominant in the opening stages and Best shot onto the roof of the net in the 20th minute after De Canio's side had failed to clear their lines.
City's young back line - with an average age of around 22 - were coping well with the threat of the Rangers attackers while at the other end, there were shouts of hand ball when Damien Delaney appeared to handle in the box under more Coventry pressure.
Moments later, Camp saved well at the feet of Mifsud, before the former England Under 21 keeper was again called into action, this time when he saved at the feet of Best when he was clean through one on one.
There was no doubt that Coventry were dominating proceedings in a first half where Andy Marshall didn't have a save to make.
Best shot again but it was a tame shot for Camp to hold, before with five minutes before the break, Doyle unleashed a firm effort from the edge of the box which again couldn't get past the shot-stopper.
Tabb was the next player to test Camp - but the former Derby County keeper was in excellent form and kept out his firm shot.
Having dominated but failed to break the deadlock in the opening 45, City came out looking to press play at the start of the second period but saw QPR playmaker Akos Buzsaky send a dipping volley just over the bar on 52 minutes.
The Sky Blues had a good spell of pressure around the hour mark and when Mifsud broke free down the right, he centred for Best who could not reach the cross with his head and was booked for deliberate handball.
Thornton was being his usual creative self in midfield and played substitute Julian Gray away with a beautifully weighted pass as the game entered the final 10 minutes, but the winger's cross failed to pick out a City man.
The former Birmingham man did better with his next delivery but on this occasion there was no City forward attacking his fierce ball across the face of goal.
There were many positives to the Coventry performance, such as a near-immaculate defensive display but the Sky Blues certainly had enough of the ball and good enough chances - in the first half especially - to leave a nagging feeling that this was two points dropped rather than a point gained.
COVENTRY: Marshall; Fox; Ward; Hughes (c); Doyle; Osbourne; Mifsud; Tabb (Gray 75); Best; Dann; Thornton. Subs (not used): Konstantopoulos; Hall; Andrews; Simpson
Booked: Best (62)
QPR: Camp; Delaney; Mancienne; Buzsaky; Rowlands (Ainsworth) (c); Connolly; Agyemang (Blackstock 86); Ephraim; Vine; Hall; Leigertwood. Subs (not used): Pickens; Barker; Stewart
Booked: Connolly (54); Buzsaky (70)
Attendance: 15,225 (1,106)
